Standardized
Corosolic Acid (1%)
Study
In 1998, a crossover, placebo-controlled clinical study was
conducted at the Tokyo Jikeikai Medical School in Japan with
24 subjects. The criteria for including subjects in this study
were mild case of insulin independent diabetes, inability
to tolerate glucose burden, glucose levels of 110mg/deciliter
(fasting level) and subjects older than 20 years of age.
The
subjects were given orally either a placebo or 3 tablets of
250mg each, after each meal three times daily. The daily total
dose of Corosolic acid was 0.16 mg, the active ingredient
of the Banaba Leaf extract. The results of this study clearly
demonstrate that Banaba Leaf extract is effective in reducing
blood glucose levels even in short-term (4 weeks) treatment,
with no signs of adverse effects.
Furthermore,
even a one-time dose leaves a memory-effect for blood glucose
control. Compared to the placebo group, a statistically significant
drop in the average blood glucose level is observed with the
administration of Banaba Leaf extract. Blood glucose levels
dropped from 153.9 mg/deciliter, before the Banaba Leaf extract
dose, to 133.1 mg/deciliter, after the dose.
